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Oxidative stress as the primary cause has been observed in atherosclerosis and radiation-induced diseases such as lung injury

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.,MailletAPervaizSRedox Regulation of p53, Redox Effectors Regulated by p53: A Subtle Balance.2012;16(11):12851294

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Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization